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Adults (aged 18 years) with a BMI 27 kg/m 2 and glycated hemoglobin (HbA 1c ) of 710% (5386 mmol/mol) were randomly assigned (1:1:1), to receive either once-weekly, subcutaneous tirzepatide (10 mg or 15 mg) or placebo for 72 weeks
Conversely, if weight loss is the priority, establishing this treatment first may be preferable
If tirzepatide can reduce oral contraceptive absorption by 60%, it can affect oral HRT absorption as well
