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Ussing chamber study Nonfasted mice were dissected under isoflurane anesthesia, and the cecal tissue was removed and washed well with Krebs Ringer solution (117 mM NaCl, 5.9 mM KCl, 2.5 mM CaCl 2 , 1.2 mM MgCl 2 , 24.8 mM NaHCO 3 , 1.2 mM NaH 2 PO 4 , and 11.1 mM glucose)

Studies in Cambridge were supported by the Rosetrees foundation (to HYY and GL) and an international scholarship from the Cambridge Trust (HYY)

PEG modification increased the stability of protein and peptide drugs, increased the solubility, reduced the immunogenicity, prolonged the residence time in blood, reduced the protease degradation, and reduced the frequency of drug use

Whilst current evidence shows no established causal link between GLP-1 agonist use and these haematological conditions, individualised assessment remains essential for patients with existing lymphoproliferative disorders or those at risk