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Recent studies on Citrus aurantium indicate that the hexane fraction of CA (HFCA) stimulates NCI-H716 cells and induces membrane depolarization in NCI-H716, resulting in the secretion of glucagon-like peptide-1 (GLP-1), which regulates insulin secretion in pancreatic beta-cells

Tirzepatide (Mounjaro, Zepbound) activates two: GLP-1 and GIP

(2), with pGCG = plasma glucagon level, k = slope of the regression line at baseline of SUV 55min (SUV 55min, Baseline ) over plasma glucagon (pGCG Baseline ) Estimation of slope k was based on all n = 13 subjects for whom SUV 55min and plasma glucagon values were available at baseline

As future doctors, we are taught to always warn patients on sulfonylureas about hypoglycemia symptoms shakiness, sweating, confusion and to always carry sugar with them. Mohammad Junaid Rain, MBBS 2nd Year Key advantages of Sulfonylureas: Very affordable 30100/month in India Available everywhere even in small town pharmacies Strong blood sugar lowering effect Decades of safety data Key disadvantages: Hypoglycemia risk can cause dangerous low blood sugar Weight gain 24 kg on average Beta cell burnout with long term use, pancreas gets more exhausted Not ideal for elderly patients or those who skip meals Hypoglycemia warning signs to tell your patients: What to do: Immediately eat 23 teaspoons of sugar or drink a glass of fruit juice