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JPMorgan's Schott said tolerability is the "key focus" for doctors, patients, and investors examining orforglipron's phase 3 data, with a goal of nausea rates below 25% and vomiting rates in the low double digits for diabetes patients

As per estimates, the prevalence of MAFLD among adults in general ranges from 25 to 30%, while the occurrence of underlying nonalcoholic steatohepatitis (NASH) is estimated to be between 3% and 6%

While microdosing is a common, colloquially-used term, specifics on reduced frequency and/or dosing after initial weight loss is still emerging. The Bottom Line on Microdosing GLP-1s Research on GLP-1s for weight loss is, overall, promising

Metabolic adaptation also plays a significant role in post-treatment weight gain