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Summary: The half-life of retatrutide is approximately 6 days, based on pharmacokinetic data from Phase 1 and Phase 2 clinical studies, which supports its once-weekly subcutaneous injection regimen

The PSA and the cost-effectiveness acceptability curves suggested that subcutaneous tirzepatide had a larger potential of being cost-effective when compared with oral semaglutide, with a 97.8% probability at a WTP of $150,000 per QALY at 68 weeks

We could not confirm a direct role for GLP-1, which was reported in other studies [6, 10]

Needle depth awareness: Semaglutide pens come pre-set, but ensure you're gently pinching the skin to isolate the subcutaneous fat away from the underlying muscle