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Peptide hormone exendin4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinsons disease

Whether orforglipron's effects on bone health are net positive (through receptor-mediated bone protection) or net negative (through sustained caloric deficit and weight loss reducing mechanical loading on bones) will need to be determined through long-term surveillance studies

P = 0.0005) [45]
In contrast, those who took orforglipron regained just 26%, with over two-fifths of participants maintaining over 80% of their body weight reduction
