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Benefits of prescription peptide medications for weight loss include : Significant weight loss ( 5%20% in less than a year and a half) Steadier blood sugar levels Reduced food cravings Reduced waist circumference Less body fat, including belly fat (though some lean muscle mass loss may also occur) Lower blood pressure and cholesterol levels Reduced risk of other weight-related health conditions, such as heart disease Slowed progression of kidney disease in people with type 2 diabetes Improvement in obstructive sleep apnea and fatty liver disease (metabolic dysfunction-associated steatohepatitis, or MASH) May help improve symptoms of osteoarthritis Side effects of prescription weight loss peptides While GLP-1s and GLP-1/GIP medications are generally well tolerated, they can cause side effects, some of which can be serious