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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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A Renewed Look at an Old Controversy Ever since GLP-1 receptor agonists (GLP-1 RAs) entered clinical practice for diabetes and obesity, their metabolic benefits have been undeniable

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