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Actionable Tip: Aim to include a high-quality protein source in every small meal or snack

Include fermented foods regularly to maintain the bacterial populations that convert fiber into GLP-1-triggering SCFAs

Autocrine interleukin-10 mediates glucagon-like peptide-1 receptor-induced spinal microglial beta-endorphin expression

In addition, our previous studies revealed that microglia and their purinergic receptors (P2 4R, P2 7R and P2Y12R) were significantly upregulated in the TNC after NTG injection, and inhibiting microglial activation, including morphological and inflammatory changes, might affect neuronal hyperexcitability in the TNC, which ultimately relieved CM-associated allodynia [17,18,19]