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A phase 2, randomised, double-blind, placebo-controlled, dose-ranging study evaluating retatrutide was published in the New England Journal of Medicine (NEJM) in June 2023 (Jastreboff et al
WMD = 2.30 kg, 95% CI 0.53 to 4.07, P = 0.01, 2 = 0.0%
it reflects the reward-pathway mechanism at work
Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis
