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The clinical development of retatrutide includes: - A multiple-ascending dose phase 1b clinical trial in subjects with type 2 diabetes - Phase II clinical trials for obesity, which demonstrated significant weight reduction (average weight loss of 17.5% at 24 weeks and 24.4% at 48 weeks) - Phase III trials for treating type 2 diabetes mellitus, non-alcoholic fatty liver disease, and obesity, which began on August 28, 2023 Cotadutide Cotadutide is a peptide co-agonist that acts on GLP-1 and glucagon receptors