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Among the plethora of novel agents against diabetes, GLP-1RAs are known to exert various biological effects in extra-pancreatic tissues beyond controlling hyperglycemia ( via central mechanisms ( Similarly, SGLT-2is, also referred to as gliflozins, represent another class of anti-hyperglycemic agents currently used in T2D treatment with favorable effects on body weight

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Walker A.K., Ibia I.E., Zigman J.M

By enhancing gut barrier function, GLP-1 RAs cut off a major source of inflammation, the leaky gut, thus helping to resolve metabolic inflammation (107)

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