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Hepatology 70(5):15311545

The greatest concern is that while in the short-term the program could provide health benefits to those who need help with weight management, in the long-term those same problems could return if there is a failure to extend the program past its current end date, Beene said

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Chronic administration study Finally, to determine whether exendin-phe1 beta cell effects persist with chronic administration, we administered agonists continuously to HFHS-fed mice for 2 weeks via subcutaneous minipumps, using a relatively low dose of agonist (0.24 nmol kg 1 day 1 ) to reduce the weight-dependent effects