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A trans-3-hexenoyl group attached to the N-terminus gives Tesamorelin significantly greater resistance to enzymatic degradation than native GHRH.nnIt is the only GHRH analog currently approved by Health Canada and the FDA, marketed under the trade name Egrifta (and the related Egrifta SV and Egrifta WR formulations) by the Canadian biopharmaceutical company Theratechnologies for HIV-associated lipodystrophy