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Glucagon Activity Glucagon is often discussed in relation to raising blood glucose, but it also has complex roles in energy balance and metabolism

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These gastrointestinal effects result from tirzepatide's mechanism of action, specifically its slowing of gastric emptying and effects on satiety centers in the brain

First-Line, Second-Line, and Alternative Approaches First-Line Options: Lifestyle modification (calorie tracking, physical activity) GLP-1/GIP medications (e.g., Zepbound, Mounjaro) Second-Line: Semaglutide (Wegovy/Ozempic) Liraglutide (Saxenda) Phentermine-topiramate Alternative (or Adjunctive): Metformin (for insulin resistance/PCOS) Bupropion-naltrexone (appetite regulation) Bariatric surgery (in select patients) At Health Express Clinics, we tailor treatment based on individual metabolic profiles, access to medications, and patient goals