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A 2021 meta-analysis in Obesity Reviews examining probiotic supplementation for weight management found small effectstypically 0.5 to 2 kg greater weight loss compared to placebo over 8-12 weeks
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On the other hand, younger individuals (aged 1850) using GLP-1RA demonstrated a significantly higher composite risk compared to DPP-4i users (HR: 1.553, 95% CI: 1.3621.771) than those older than 50 years (HR: 1.174, 95% CI: 1.0971.256) (Additional file 2: Fig
