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Studies suggest that GLP-1RAs dont adversely affect bone mineral density and may be associated with a reduced risk of fractures [14]
The first several minutes cover the reward-pathway mechanism most directly relevant to the craving signal described above

doi: 10.1111/apt.17598

In a healthy state, SCFAs send calming, anti-inflammatory signals up the vagus nerve, promoting parasympathetic ("rest and digest") tone
