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Weight cycling is harmful (the cycle of losing weight then regaining the weight) and may be linked to: Higher body fat percentage and slower metabolism over time weight loss involves losing both fat and muscle weight regain is mostly gaining fat body image issues and further weight cycling Greater risk for cardiovascular disease and insulin resistance Emotional distress and disordered eating patterns Its important to create and maintain personalized, long-term strategies that focus on behavioral changes and mindset shifts before, during, and after stopping GLP-1 medications

Do not aspirate for subcutaneous injections (aspiration is not required and may increase discomfort) [13]

The absence of clinical trials and comparative studies evaluating the efficacy of GLP-1 agonists in treating HS has hindered the ability to conduct a meta-analysis

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