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[DOI] [PubMed] [Google Scholar] 80.Samms RJ, Christe ME, Collins KA, et al
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Patients with PD primarily exhibit a significant loss of insulin receptor mRNA in the substantia nigra pars compacta, increased insulin IR, and reduced activation of molecules such as insulin receptor substrate 1 (IRS1) and protein kinase B (Akt) within the insulin metabolic pathway (24)
When Staying Longer At A Dose Works Better Than Escalating Its a common assumption that increasing the dose is the best way to break a plateau
