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The positive allosteric modulators (PAMs) are as follows: LSN3451217 (4-[(3 S )-2-[(2-hydroxy-4-isopropyl-phenyl)methyl]-6-methoxy-3-(methoxymethyl)-3,4-dihydro-1H-isoquinolin-5-yl]-2-methyl-phenol, hydrochloride salt) and LSN3556672 (2-fluoro-6-(isobutylamino)-4-[(1 R )-2-[(1 S )-1-(4-isopropylphenyl)ethyl]-6-methoxy-1-methyl-3,4-dihydro-1H-isoquinolin-5-yl]phenol, dihydrochloride salt)

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They cannot bind to receptors properly, cannot be absorbed efficiently, and in some cases can provoke unwanted immune responses