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It reflects how each medication interacts with hormone pathways that influence appetite, insulin response, digestion, metabolism, and possibly energy expenditure
The long-term safety signals from STEP 5 and from the larger SUSTAIN diabetes database are reassuring but not definitive five-year and ten-year data continue to accumulate as more patients enter long-term treatment

Efficacy and safety of glucagon-like Peptide-1 receptor agonists in the treatment of metabolic associated fatty liver disease: a systematic review and Meta-analysis
