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However, the reality is that it takes decades to accumulate pharmacological long-term safety data

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To explore the potential impact of titration timing on clinical outcomes, early and late escalation groups were defined using the cohort median as the cutoff, as there is presently no established clinical consensus defining rapid versus delayed escalation

February 2026 marked a meaningful expansion in the oral GLP-1 landscape, with new data adding to the momentum that began with the FDA approval of oral Wegovy (semaglutide 25 mg tablets) in late 2025