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2.1.5 Ritlecitinib Ritlecitinib is an oral selective JAK3/TEC family kinase inhibitor studied in the VIBRATO trial (NCT02958865), a Phase 2b double-blind placebo-controlled RCT umbrella study that evaluated its efficacy in moderate-to-severe UC patients aged 1875 years with a total MS 6, RBS 1, and MES 2

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