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Description
According to the SURMOUNT-5 trial published in May 2025, participants on the maximum tolerated dose of Semaglutide (1.7 mg or 2.4 mg) achieved an average weight loss of 13.7% over 72 weeks

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Most protocols recommend monthly increases until reaching 10-15mg or until side effects necessitate holding at current dose

Triple agonists Retatrutide adds glucagon receptor activation to the GLP-1/GIP combination
