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Thus, in addition to a direct role of the paraventricular hypothalamic nucleus to regulate energy balance and glucose metabolism, neurons in the paraventricular hypothalamic nucleus function as an important relay for various circuits including melanocortin neurons, which contribute to proper metabolic regulation

The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control

Currently, 71.2% of US adults (20 years of age) were found to be overweight or obese [9], representing a massive public health challenge with profound economic implications

However, this potential benefit has not yet been well studied