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In contrast, GLP-/GIP dual agonists, while controlling blood sugar, can more comprehensively regulate lipid metabolism and reduce the risk of cardiovascular diseases [138,139]

GIPR agonists In contrast to the results inferred from the obesity-promoting effects of GIP, it has been shown that transgenic mice overexpressing GIP exhibit a significant decrease in weight gain after ingestion of an HFD, suggesting that chronic elevation of GIP levels well above physiological concentrations may exert a centrally mediated suppressive effect on appetite [124]

8:19-28 [PMC free article: PMC8109335] [PubMed: 16407685] 88

However, this event was associated with the concurrent use of ondansetron (an anti-nausea medication), not directly attributable to retatrutide itself