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A particular alteration involves lysosomal dysfunction, which hinders the degradation of structurally damaged mitochondria, leading to cellular toxicity ( In AD, dysfunctional mitochondria accumulate and exacerbate lysosomal degradation bottlenecks

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A 2024 case series in Journal of Clinical Endocrinology reported that patients receiving combination therapy showed 18% greater fat mass reduction compared to GLP-1 monotherapy, with improved energy scores on validated fatigue assessments (Morrison et al., 2024)

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