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The Power of Combination: The S-LiTE Trial Research published in JAMA Network Open (Sandsdal et al., 2023) and The Lancet Healthy Longevity (Jensen et al., 2026) compared GLP-1 use alone versus GLP-1 plus exercise: Body Composition: The "Exercise + GLP-1" group reduced abdominal fat by 6.1% , nearly double the results of the medication-only group

Semaglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes, has become one of the most prescribed injectable medications for weight management

With seven additional Phase 3 trials expected to read out in 2026, Retatrutide is positioning itself as potentially the most effective obesity medication ever developed

Recent technological advances for GLP-1s include microneedle-assisted delivery systems, the researchers wrote.