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Description
Epidemiological data suggest that patients with HFrEF who are at CKD stage 4 and 5 have a 50% survival probability over 20 months, in contrast to patients with HFrEF without CKD in which about 75% are still alive after 20 months [49]

As discussed above, lipopolysaccharides (LPS) could prompt inflammation and amyloidogenesis in the brain, by inducing the disorder of TNF-a, IL-1, and cyclooxygenase-2 (COX-2) (87)
When theres not enough water in the body, this process is disrupted

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