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The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes

Unlike semaglutide, which targets only the GLP-1 receptor, tirzepatide is a dual GIP/GLP-1 receptor agonist that targets both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Using the avocado to test the satiety effects of a fat-fiber combination in place of carbohydrate energy in a breakfast meal in overweight and obese men and women: A randomized clinical trial