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GLP-1 medications have been shown to be safe for long-term use in many individuals

Avoiding high-fat and spicy foods, citrus, chocolate, and caffeine can reduce acid irritation of the esophageal lining

Proof of principle for the synergistic interaction of these 2 systems also in males comes from data showing that GLP-1-estrogen conjugate applied peripherally or directly to the CNS has superior effects of body weight loss, fat mass, or food-motivated behavior suppression in males (41, 42)

However, your provider should monitor blood pressure regularly, as weight loss may eventually require dose reductions in your blood pressure medications to prevent hypotension