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Many people report more pronounced hangover symptoms on retatrutide, likely due to several factors: prolonged exposure to acetaldehyde (the toxic intermediate in alcohol metabolism), extended gastric emptying time creating prolonged GI distress, dehydration effects amplified by the medications impact on kidney function, and the general nausea tendency of GLP-1 agonists being triggered by alcohols aftereffects

What Each Medication Does Ozempic Ozempic contains semaglutide, a GLP-1 receptor agonist that works by mimicking a gut hormone released after eating

For others, tirzepatide may produce stronger results

What are the tirzepatide vs semaglutide side effects