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Loss of CNS GIPR augments weight loss with GLP-1R agonism To examine whether CNS GIPR is required for the additive weight loss effect of combination treatment with mGIPR-Ab and clinically approved GLP-1R agonists, HFD-fed Gipr fl/fl control mice and Gipr Syn/ mice received IP dosing of either vehiclevehicle, dulaglutidevehicle or dulaglutidemGIPR-Ab combination treatments
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Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect
10.1097/MCO.0000000000000574 [DOI] [PMC free article] [PubMed] [Google Scholar] 44.Almby KE, Abrahamsson N, Lundqvist MH, Hammar U, Thombare K, Panagiotou A, et al
