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This happens because appetite suppression is temporary while hormones, insulin signaling, and gut health remain uncorrected

The ongoing FOCUS trial investigates the long-term effects of semaglutide compared with placebo on diabetic retinopathy, including relatively well-regulated (HbA1c 710%) patients with T2D (51)

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This has also been suggested by a guideline of the Italian Society for the Study of Diabetes and the Italian Endocrinological Society (30) and their side effect of genitourinary infections may be especially disadvantageous in patients with Cushings syndrome who are already at an increased risk of infection