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Furthermore, insulin resistance and hyperinsulinemia are critical contributors to the increased androgen secretion observed in this population [39]

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In a randomized, double-blind, placebo-controlled phase Ib/IIa study (NCT05943886), the GLP-1/FGF21 dual agonist HEC88473 was generally safe and well tolerated in patients with MASLD

If you have diabetes and take tirzepatide with other glucose-lowering medications, your provider will likely reduce doses of those medications to prevent hypoglycemia