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[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Joshi GP, Abdelmalak BB, Weigel WA, et al

Second, Akt phosphorylates and inactivates FOXO1, a transcription factor that would otherwise enter the cell nucleus and turn on MuRF1 and Atrogin-1 gene expression

TBR, time below range

Shaking creates foam, introduces air bubbles, and can denature the peptide through mechanical stress
