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Consistent data on long-term use in children are limited, though adult studies report discontinuation rates between 37% and 81% at one year due to factors like cost, insurance, comorbidities, and absence of type 2 diabetes [83,84,85]

The 19 identified GLP-1 RA-related NAEs are not documented in approved labeling, expanding on prior evidence

After reconstitution with bacteriostatic water, refrigerate at 28C and use within 28 days

43 In the STEP 1, 3, 4 and 8 trials (the 68week long trials in participants without diabetes), weight loss of 5% (a threshold widely accepted as indicating clinically meaningful response to therapy) 46 was achieved by 86%89% of participants receiving semaglutide 2.4 mg versus 29%48% receiving placebo (Table 2)