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Nature Medicine 30(6):1761-1770

Despite the limitations of the single-blind design in this clinical study, the advantages in exenatide-treated group in both cognitive and motor functions persisted in the follow-up study after a 12-mo wash-out period. 99 This suggests disease-modifying effects of exenatide, and the results are encouraging enough that a subsequent double-blind clinical study (NCT01971242) was initiated by the same investigators using a sustained release formulation of exenatide ( Bydureon : 2 mg administered subcutaneously once weekly) to evaluate in a similar group of PD subjects over a similar duration of time

Several critical domains showed consistently low ratings
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In addition, most current approaches for analyzing gut microbiome data rely on comparisons to reference genomes 36
