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Once the data is sufficiently acceptable the cost-benefit analysis for the insurers is impossible to ignore they will begin covering these drugs widely, and the benefit to the patients will show up in terms of savings

22 However, the fact that the magnitude and speed of hemoglobin A1c reduction with treatment were identified as risk factors for progression suggests it could be another example of the well-established early worsening phenomenon first observed in type 1 diabetic patients intensively treated with insulin in the Oslo Study, Kroc Collaborative Study and Diabetes Control and Complications Trial