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Description
Insulin signaling directly influences immune cell metabolism, macrophage polarization, and T-cell differentiation, thereby shaping inflammatory responses within musculoskeletal tissues ( Increasing evidence from immunometabolic research supports a bidirectional relationship between metabolic dysfunction and inflammatory arthritis, whereby chronic inflammation promotes insulin resistance, which in turn amplifies synovial and entheseal inflammation ( Figure 1 , insulin resistance, adipose tissue inflammation, and impaired incretin signaling converge at the skinjoint axis to amplify IL-23/IL-17driven immune activation and disease progression

Yes, both semaglutide and tirzepatide are excellent choices for patients with type 2 diabetes

The ECL3 of the GLP-1R:TT-OAD complex was removed for clarity

A retrospective study suggests that GLP-1 use amongst those with overweight or obesity was linked to a substantially lower risk of breast cancer
