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In agreement, a recent study showed that intra-ileal infusion of GLP-1, or chemo- or optogenetic stimulation of ileal L cells, induced gastric distension via activation of GLP-1R on local intestinofugal enteric neurons and sympathetic ganglion activation, which in turn led to anorexia via a spinal afferent neuron to hypothalamus circuit (53)

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Newer drugs like tirzepatide (sold as Zepbound and Mounjaro) combine GLP-1 drugs with glucose-dependent insulinotropic polypeptide (GIP) receptors to increase potency

It may offer prescription medications and is designed for people who need guided medical support alongside the lifestyle changes that Noom Weight supports