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IR D707A/+ mice were crossed with IR floxed mice (IR F/F) and a tamoxifen-inducible Cre recombinase (Cre-ERT) line to generate IR D707A/F, IR D707A/F;Cre-ERT, and IR F/F;Cre-ERT mice (Fig

This establishes one more time that allulose effects in humans are less likely as impressive as shown in rodents in which usually unrealistic high doses of allulose are administered

They are effective as monotherapy in younger patients and those with mild-to-moderate PD

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