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PMID: 28711425 Ehrenpreis ED, et al
While it is generally safe, melatonin is a potent hormone, originally extracted from a cows pineal gland, and it can have a number of adverse effects and drug interactions, ranging from nausea to increased blood pressure
In recent years, an oral formulation of a long-acting basal insulin analog (IO338) with the permeation enhancer sodium caprate was shown in a phase II study to have comparable efficacy to subcutaneous insulin glargine [47]
Nausea rates (~46% vs ~44%) are similar, while diarrhea may be slightly more common with retatrutide
