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GLP-1 RAs also exert pleiotropic actions with metabolic, hepatic, renal and cardiovascular beneficial effects [4,5,6,7]

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Wright commented that [t]he precise mechanism of these improvements remains speculative but does not appear to be purely related to weight loss. Indeed, he added, much of the benefit in these patients with heart failure seemed to be manifest prior to any substantial weight loss, strongly suggesting that the GLP-1 receptor agonist led to improvements in the metabolic syndrome and the heart failure syndrome, independent and perhaps additive to those expected from weight loss. Mir Ali, MD, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, not involved in this research, welcomed its findings