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GLP-1R agonists promote CICR in a Ca 2+ -dependent manner, requiring a rapid increase in intracellular free Ca 2+ concentration to mediate Ca 2+ release from intracellular stores [85,89]
Journal reference: Berning P
This depolarization is propagated through voltage-dependent Calcium and Sodium channels, which currents lead to the discharge of the hormones containing vesicles (72)
