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Description
The mice were group-housed in ventilated cage (3-5 mice per cage) with a 13 hr light/ 11 hr dark cycle (lights on at 07:00) at 22 1 C and 55 10% relative humidity in the specific pathogen-free (SPF) animal room in the Laboratory Animal Center, National Cheng Kung University (NCKU)

Yet 6 to 7 weeks of daily treatment with semaglutide (escalated from 41 g/kg to 103 g/kg) or tirzepatide (escalated from 12 g/kg to 48 g/kg) did not produce any noticeable effect on these readouts, including Iba-1 activation, in 12-month-old 5XFAD and APP/PS1 mice (51)

Genetics 198:11271153

Peptide solutions are generally stable for up to 30 days when refrigerated at 4C (39F), but those peptides with inherent instability should be kept frozen when not in use