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Food and Drug Administration (FDA) approved the GLP-1 medication semaglutide in 2021 for treating obesity

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GLP-1, a hormone secreted by the intestines, lowers blood glucose and promotes weight loss through multiple mechanisms: it enhances insulin secretion in a glucose concentration-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces food intake via central appetite suppression

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The primary endpoint was the percentage weight loss at six months (M6) compared to baseline

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