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Indeed, in transfected HEK293 cells expressing the same levels of GLP-1R or GIPR, and at two vastly different receptor densities (obtained with either 0.5 mg or 10 mg receptor cDNA transfections), it was determined that GLP-1R induced the formation of approximately double the amount of cAMP the GIPR induced, with the surface expression (B max ) levels being equal for both receptors [42]

doi: 10.3389/fphar.2026.1798309 Received 28 January 2026 Revised 27 February 2026 Accepted 28 February 2026 Published 26 March 2026 Volume 17 - 2026 Edited by Marcos Roberto De Oliveira, Federal University of Rio Grande do Sul, Brazil Reviewed by Maria Jos De Rosa, CONICET Baha Blanca, Argentina Shubham Teli, BVVS Hanagal Shri Kumareshwar College of Pharmacy, India Updates Copyright 2026 Juthi, Ansari, Ahmed, Khan, Seidel, Kumar, Kumari, McKillop, Abdel-Wahab and Flatt

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Kushner has spent more than four decades treating patients with obesity and training clinicians in obesity care