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For uninsured patients, compounded semaglutide from a 503A pharmacy delivers equivalent clinical efficacy at a fraction of the out-of-pocket expense, typically $149$189 per month versus brand-name copays or cash prices exceeding $900 monthly

Retatrutide decreased HbA1c by 2.02% in a phase II clinical trial, while dulaglutide 1.5 mg decreased HbA1c by 1.14% and a placebo decreased it by 0.01% [109]