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IGF-1 signaling is widely studied because it plays a role in protein synthesis and tissue repair processes

For instance, Medicaid has moved in the opposite direction: Only 13 states cover GLP-1s for obesity treatment as of early 2026, down from 16 in late 2025

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However, the optic nerve may be uniquely vulnerable to changes in perfusion, autoregulation, metabolic status and local anatomic susceptibility, and favorable systemic vascular effects may not necessarily translate into reduced optic nerve ischemic risk. Beyond their cardiovascular benefits, GLP-1 agents may also influence ocular microvascular physiology